Are you running the wpfc option?
If so.. what is your w3tc setup?
Some say enabled database cache slows down backend, for me this was the case.
w3tc should be left alone, with one exception - cdn setup. Utherwise i found it best to leave the settings as is.
Also minification is better so setup with "Autoptimize", "Above The Fold Optimization" and "Google Web Font Optimization"
These all work well together and when properly setup on a good web stack your wp is blazingly fast
Peace =)